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Which Stage of Grief are you in regarding computer component prices?

  • Denial: "I don't need a new GPU, in fact I'm looking forward to running GTA 6 in 8-bit mode"
  • Anger: You rage post to SN about the economic model that allows future production to be tied up by money that doesn't yet exist
  • Bargaining: You convince yourself that you don't need side panels or a fan for your case so that you can throw that extra money towards another stick of RAM
  • Depression: You sit up at all hours of the night hitting refresh on your digital shopping cart hoping to see the "Out of Stock" message disappear
  • Acceptance: You realize your current PC is now your forever PC and you vow to nurse it along with compressed air and prayers until at least 2035
  • Other: Describe in comments

[ Results | Polls ]
Comments:84 | Votes:188

posted by jelizondo on Friday October 30, @06:13PM   Printer-friendly
from the favorite-fruit-flavored-technology dept.

https://www.raspberrypi.com/news/emulate-apple-ii-on-raspberry-pi/

The Apple II was not the first personal or home computer, but it was part of the iconic 'trinity' of computers that came out in 1977: Apple II, Commodore PET, and TRS-80.
[...]
In designing the Apple II, Steve Wozniak took inspiration from his work on the Breakout arcade game during his time at Atari. It's why the Apple II has colour graphics, support for paddle controllers, and even audio.
[...]
The Apple II included a version of the BASIC language that only supported integer numeric data types: by eschewing floating-point numbers, Wozniak's Integer BASIC, as it was called, processed numbers extremely fast. This made it less than ideal for certain programming tasks, but it was fantastic for video games.
[...]
For Apple II emulation on Raspberry Pi, we are using the LinApple emulator. It's a fork of the AppleWin emulator which was originally created by Mike O'Brien. David Baucum (maxolasersquad) and several other contributors got it running on Linux. You may also want to have a look at audetto's fork of the AppleWin emulator. Because audetto's fork is regularly synchronised with the original AppleWin GitHub repository, it tracks AppleWin features more closely.
[...]
Here's a little BASIC program you can try running. You can either type it into the emulator, or you can find the program in the ch03/AppleIIBasicPrograms.dsk file in the GitHub repository.
[...]
This will draw a small square on screen. Use the W, A, S, and D keys to move it around the screen. The program is quite simple.
[...]
After you run a graphical program, you'll only have a small text area below the graphics mode portion of the emulator screen. You can type the TEXT command and press ENTER to return to text-only mode. You'll also find these commands helpful:

        LIST — lists all the lines of the current BASIC program.
        RUN — runs the current program.
        NEW — erases the current program and lets you start afresh.
        CATALOG — lists all files on the disk image.
        SAVE NAME — saves the current BASIC program under whatever file name you specify.
        LOAD NAME — loads the program with the specified file name.
        CTRL+C — use this key combination to stop a running BASIC program.

Apart from CATALOG, these commands only apply to BASIC programs. Many games are binary executable files that don't include BASIC source.

You can find some fun type-in programs in Lee Fastenau's collection of short programs.
[...]
This tutorial is part of a series of emulation guides in The Raspberry Pi Guide to Retro Gaming — a definitive guide on how to play your favourite games of yesteryear on a Raspberry Pi. You can also find it in the latest issue of Raspberry Pi Official Magazine.


Original Submission

posted by jelizondo on Friday October 30, @01:30PM   Printer-friendly

The findings suggest possible surveillance interest in countries where Starlink is banned or restricted.

Discover-Tech, an Israeli advertising firm previously linked to the delivery of zero-click spyware, is the top bidder for Starlink ad impressions in 105 countries, according to a new report from Reuters. Researchers say it all points to a large-scale tracking effort aimed at users of SpaceX's satellite internet service.

John Scott-Railton, a senior researcher at the University of Toronto's Citizen Lab, posted on X that data from TrendAI suggest the existence of a "worldwide surveillance op targeting @Starlink users."

Discover-Tech was previously named in Citizen Lab's October 15th report as the buyer of ordinary-looking ads that delivered Candiru spyware to devices at Al Jazeera without any user interaction. Candiru is an Israeli mercenary spyware vendor (now rebranded as Integrity Labs) that develops tools capable of silently compromising phones and computers. In 2021, the U.S. Department of Commerce's Bureau of Industry and Security added Candiru to their trade restriction list, known as the Entity List, over concerns it supplied surveillance technology used against journalists, activists, and government officials.

[Source]: GIZMODO


Original Submission

posted by jelizondo on Friday October 30, @08:49AM   Printer-friendly

https://www.engadget.com/2295033/warhound-genetically-engineering-dogs-military/

Warhound, a new startup that has just raised $200 million in funding, aims to genetically engineer war dogs for the US military and fit them with high-tech gear. It's a project by Colossal Biosciences' Ben Lamm and Anduril's Palmer Luckey. Lamm has told Wired that Warhound has already started editing genes of the cell samples taken from its first batch of donor dogs. Specifically, the startup collected samples from top-performing military, police and first responder dog breeds in the US, mostly Belgian Malinois, some labradors and some shepherds. The goal is to clone them after scientists working for Colossal have tweaked their genes.

Those scientists will initially focus on making them less likely to develop health conditions that commonly affect their breeds, such as hip dysplasia and certain cancers. In the future, Lamm thinks the dogs could be enhanced further. Scientist could incorporate more genetic changes to make them faster and more agile or to enhance their sense of smell, Lamm told TechCrunch.

Luckey, if you'll recall, founded Oculus VR and designed the Oculus Rift headset. His company Anduril teamed up with OpenAI in 2024 to develop AI for the Pentagon. More recently, it secured a contract with the US Army to create its next-gen battlefield intelligence system alongside Palantir. Meanwhile, Lamm's biotech company is behind several "de-extinction" initiatives, including one that claims to have revived the dire wolf and another that aims to bring back the woolly mammoth.

So where does Luckey's Anduril come in? Warhound doesn't seem to have plans to create cyborg dogs — for now. Anduril will be designing tools and the software powering them, which will help protect the dogs while they work. Think goggles, vests and body armor. Luckey is a partner in the business, but neither he nor Anduril has a stake in the startup. Colossal Biosciences has equity in the company, and Lamm is on its board. David Spirk, who most recently worked at Palantir, now serves the startsup's CEO.

Warhound expects its first batch of genetically engineered dogs to be born in early 2027. They will be trained to perform various tasks working dogs do, such as detect bombs and aid in search-and-rescue operations.


Original Submission

posted by jelizondo on Friday October 30, @03:55AM   Printer-friendly
from the right-in-the-pocket-book dept.

https://arstechnica.com/gadgets/2026/10/from-cheap-tool-to-premium-subscription-when-a-beloved-apps-price-skyrockets/

How much are you willing to pay to keep using your favorite app?

Maybe you've used it for years. Perhaps it performs a function so essential and specific that you couldn't imagine what you'd do without it.
[...]
Earlier this year, Evernote, a note-taking app, changed its subscription tiers, forcing some users to go from paying $130 per year to $250.
[...]
10 times more than what Evernote charged for annual subscriptions from its 2008 launch until 2016.
[...]
When Bending Spoons bought Evernote in 2023, the app had a sizable customer base. In a June SEC filing, Bending Spoons explained that it was attracted to Evernote's 200 million accounts and high user engagement.
[...]
Although price hikes risk eroding customer loyalty, Bending Spoons investigated how much change in pricing and subscription tiers Evernote users would tolerate.
[...]
Shortly after the acquisition, Evernote prices increased (from $8 per month to $15/month, or from $70/year to $130/year). The new prices aimed to better align "with how different customer segments... engage with" Evernote, and, in combination with product improvements, led to "average revenue per monthly active user being 2.5 times as high in 2025 as in 2022," Bending Spoons said.
[...]
Evernote released over 150 product updates in 2025, the filing says. Evernote v11, a huge update, came out in 2026.

While issuing layoffs in July 2023, Bending Spoons said Evernote had been "unprofitable for years." By November 2024, the app had reportedly reached record levels of profitability.
[...]
Comments from Inkdrop's developer also help explain steep price hikes imposed on longtime app users.

In 2024, the Markdown note-taking app's price doubled from $5/month to $10/month or $50/year to $100/year. At the time, Inkdrop's creator, Takuya Matsuyama, wrote a blog post
[...]
Inkdrop's developer was less concerned about growing its customer base and more interested in extracting additional revenue from current users.
[...]
Mature apps with longtime subscribers, initially drawn in through low prices and reliable features, face a predicament. Those loyal users are good for business, but they're often content with software that functions as it always has—and don't expect to pay more for it.

But stagnant growth doesn't mix well with inflation or stockholder expectations.
[...]
prices apps launch with aren't sustainable in the long term, as Plex has said about its lifetime pass, which has seen its price increase by 525 percent over two price hikes since March 2024. We've seen a similar pattern with streaming apps.
[...]
when price hikes are unavoidable, giving customers advance warning can go a long way toward showing loyal users they're valued.

Another option is to offer more subscription tiers in general. Developers often cite new features to justify higher subscription prices, but not all users want those features.
[...]
Sometimes, various internal and external factors make higher prices inevitable. When that happens, users would be wise to reexamine whether that beloved app is still the best option after all these years.

Related Stories:
DMCA Takedowns Remove Perfectly Legal Plex Pages from Google - 20210131
Critical Flaw in Evernote Add-On Exposed Sensitive Data of Millions - 20190622
Plex is Shutting Down its Personal Cloud Streaming Service - 20180912
Forget Fast-Forwarding, Plex DVR Can Now Remove Commercials for You - 20171130
Evernote, the Wounded Silicon Valley Unicorn - 20151006
Samsung Allegedly Inserts Ads into Locally-Stored/Played Movies - 20150212


Original Submission

posted by jelizondo on Thursday October 29, @11:15PM   Printer-friendly

https://www.engadget.com/2295216/most-popular-streaming-platforms-united-states-not-what-you-think/

These numbers come from Nielsen's The Gauge, which tracks viewing time on TV, not subscriber numbers, app downloads or viewing on a phone. In July 2026, 49 percent of all TV time was spent on streaming. Live channels watched via YouTube TV count toward broadcast or cable viewing, so the standalone pay TV service doesn't inflate YouTube's streaming share. It's interesting that the platform most focused on individual creators beat core streaming services so handily, especially when this is TV-only and thus doesn't include people looking up tutorials on their phones.

Disney, Paramount and Warner Bros. Discovery each have several services grouped together, while The Roku Channel and Tubi are counted individually. These numbers are for July, before Paramount (now Skydance) acquired Warner Bros. Discovery on October 6.

Despite its lower position, Peacock had a good month, with TV viewing up 15 percent from June. World Cup coverage gave it a boost, and Love Island USA had 4.9 billion viewing minutes in July. Nielsen said it was still evaluating the impact of a June change to how it measures Tubi.

YouTube reported more than 700 million hours of podcasts watched on living-room devices in October 2025, up from 400 million a year earlier. Its regular videos are free with ads, but it has no shortage of ways to take your money. You can rent or buy movies, subscribe to YouTube Premium or pay for individual creator memberships. Netflix primarily relies on recurring plans, while Prime Video offers rentals and add-on channel subscriptions.

Fox already owns Tubi and agreed to acquire Roku in a deal valued at approximately $22 billion in June. Roku confirmed on October 19 that the transaction was still pending.


Original Submission

posted by mrcoolbp on Thursday October 29, @10:08PM   Printer-friendly
from the not-a-good-time-for-Star-Trek-actors dept.
posted by jelizondo on Thursday October 29, @06:32PM   Printer-friendly
from the how.much.wood.can.a.google.chop dept.

Finland is angry at Google over illegal deforestation. Chopping down about 400 000 trees to make room for two data centers. The construction has been halted.

In addition to the 250,000 trees felled at Muhos, Annala estimates that an additional 150,000 trees were felled at Otanmäki. Because the trees have been felled illegally, she says wood from the two sites cannot be sold to wood-processing plants.

She said the system depended a lot on trust, which she believes Google took advantage of. "They bought the vast land area and they just started to cut it, just like that," she said. "It's pure arrogance and it's amazing."

Google apologized and said it acted based on its understanding of Finnish law at the time.

Google said it was working to protect water quality at the Muhos site, and that it planned to plant trees across 130 hectares there. Conservationists say that figure is too low to have any real impact in comparison to the damage done by the tree felling.

We so sorry. Promise it won't happen again, until next time. I know Finnish is hard. But don't Google offer a tool to translate it to something they can read and understand?

Jussi Kangasharju, head of computer science at the University of Helsinki, said that while datacentres brought a limited number of jobs, potentially boosting the local economy, the benefits on a national level were minimal. "Really, for Finland, there are no benefits," he said. "They are international companies serving international customers. Very little corporate taxes go to Finland. Datacentres ultimately have very little benefit for others except the datacentre operator."

No benefit.

I guess the next US export is finally here. Hating Data center buildings. All them trees gone is not going to help when the electricity bill comes ...

https://www.theguardian.com/environment/ng-interactive/2026/oct/22/finland-google-felling-trees-datacentre
https://cybernews.com/news/google-finland-data-center-trees/


Original Submission

posted by jelizondo on Thursday October 29, @01:50PM   Printer-friendly

https://www.siliconrepublic.com/enterprise/what-in-house-legal-leaders-really-think-about-ai-in-their-own-words

Multiple surveys count how many lawyers are using AI. A new report set out to ask what happens to their workload when they do.

AI isn’t replacing in-house lawyers, but the capacity it frees up is being absorbed by new work, much of it drafted by AI itself.

That is just one of the pictures to emerge from interviews with legal and compliance leaders at companies that included eir, Flipdish, Gilead Sciences, IMRO, Mastercard, Uniphar and Wayflyer for a new report, ‘From AI Adoption to AI Advantage’, produced by Dentons Ireland and SiliconRepublic.com.

Rather than creating another survey full of statistics, we set out to ask what responsible and effective use actually looks like inside a legal function today, and the results often belied the received wisdom.

Almost nobody we interviewed reported AI replacing a role or a function outright. Where it is paying off, it is mostly in repetitive work such as invoice review, contract checking and customer screening, rather than in the research, drafting and judgement calls at the heart of the job.

Sergey Kinchin, senior counsel at Uniphar, said his own thinking had changed completely in a year. “Last year I would have thought it would probably reduce headcount. Now I’m seeing it more as unlocking unmet demand,” he said. “I think the complexity of the work that’s left after AI will increase. The bottom might shift up, but the overall pyramid of work will increase and grow.”

It was a sentiment echoed by many of our interviewees. Máire Neary, who was VP of people and legal at Flipdish when she was interviewed, described treating AI “as a junior colleague, something that’s additive, that can challenge me, but you have to remember you’re the lawyer in charge at the end of the day”.

The catch is that the same tools are now in everyone else’s hands. Producing a long, polished complaint, subject access request or grievance is close to cost-free today, and the report says AI-assisted drafting now seems to touch the majority of incoming disputes, subject access requests, grievances and customer complaints.

Sorcha Nic Mhurchú, general counsel at eir, said the cost lies less in reading that material than in sorting through it. “You end up going back and having to figure out, line by line, what is relevant”, she said. “So that adds a lot of volume and time to any response, and that’s a reality for everybody, not just us.”

At IMRO, chief commercial officer Seán Donegan is glad he saw it coming. “Two years ago, I sat down with our licensing team and I said, guys, I’m going to make a prediction now,” he said. “The volume and tenacity of queries and complaints is going to increase exponentially with these AI tools.”

And it’s not just incoming correspondence. Uniphar’s Kinchin described a call with a part of the business that had gone all-in on AI “We joined a call and we had five people bring six AI-generated opinions to the call, on a question that touched a regulatory issue,” he said. “In trying to reconcile it, the AI had essentially confused itself.”

Deirdre McCarthy, chief legal and people officer at Wayflyer, added the issue is quality as well as quantity. “AI can produce so much content that sometimes looks good, but may not always be good,” she said. “So you can end up with people spending a lot of time just trading red lines because they’re putting it into their AI tool.”

Many of the interviewees remarked that this makes legal expertise all the more valuable. “In a world increasingly full of AI-generated legal content, genuine human judgement may become more valuable rather than less,” said Carlo Salizzo, head of technology and digital regulation at Dentons Ireland, speaking at a preview of the report last week.

What AI costs is easier to count than what it delivers. Flipdish’s Neary was clear about the risk of experimenting for its own sake. “I think we’ve seen a lot of AI for AI’s sake, but every lawyer, every operator, needs to ask what the return on investment is,” she said. “It’s great if your team is enjoying building and experimenting and having fun, but what have you got to show for it, particularly once you’re looking at a high LLM [Large Language Model] bill, or the cost of maintaining it down the line?”

None of the interviewees were confident they could demonstrate a return beyond obvious gains such as efficiency and risk reduction. Rebekah Dobson, head of international legal operations at Gilead Sciences, said the premise of the question itself is flawed.

“No one has proved ROI on AI as of yet because companies were not tracking the metrics prior to AI to have a starting point for setting KPIs and measuring impact of AI,” she said. “I did read an interesting article the other day that said ‘you don’t make Excel prove its ROI, it’s just there’, and I think that’s a really valuable comparison.”

Legal teams have a particular problem here, according to David Kirton, partner, technology and digital regulation at Dentons Ireland. “We tend to record the work lawyers do. We are much less good at recording the work they no longer have to do,” he said.

Cost, meanwhile, has so far only moved one way. As AI providers shift from flat licence or per-seat fees to consumption-based, token-metered pricing, bills become much harder to forecast.

Nic Mhurchú said eir feared being on a treadmill. “The licence fees and the token fees are so huge that we fear that if we start adopting and using and buying licences, we’re on a treadmill of just paying more fees, because these companies have to justify the high investment that they’ve been putting into these tools,” she said.

Jessica Williams, vice president of legal tech strategy at Mastercard, says she wants to see vendors offer more solutions and controls. “Budgets aren’t infinite and I’m going to have three or four people who are AI geniuses and they’re going to burn through tokens”.

“Then I’m going to have a bunch of other people who just do one or two things here and there … How do I balance all of that and create a predictable budget line for the company?”

Cornelius Grossmann, Dentons’ global head of solutions development, expects AI costs to rise two- to fivefold within two years and warned of a coming ‘cost cliff’. “I think the whole token economics will mean we’ll probably hire people to monitor AI cost in a big law firm,” he said. “And others may need to do that too, because it could bankrupt you if you don’t pay attention.”

Wayflyer’s McCarthy expects token spend to become the next big management question. “I think this is the next interesting wave, what we spend on AI and who gets to spend what, based on the tasks at hand?” she said.

It was a sentiment echoed by Dentons’ Kirton. “Who gets access? Which tasks justify the cost? How do you allocate consumption across a business? And how do you prevent successful adoption from producing an unexpectedly large technology bill?” he asked, adding that many legal leaders are still working out how to manage that exposure without throttling hard-won AI adoption.

Overall, interviewees described something more demanding of both sides of the client and law firm relationship: a renegotiation of who does what, who is trained for what and who pays for what, conducted in real time while the technology changes apace.

“It is probably fair to say that the legal function has not been transformed by technology to quite the same extent as areas such as finance, sales or procurement,” said Dentons’ Salizzo. “AI may be the catalyst that changes that.”

The full report is now live and can be downloaded here.


Original Submission

posted by jelizondo on Thursday October 29, @09:07AM   Printer-friendly

https://www.theregister.com/cyber-crime/2026/10/20/auto-tech-startup-claims-it-traced-hack-attempt-back-to-rivals-ip-address/5304281

An automotive tech startup claims that its IT systems were attacked by individuals trying to steal its driving model, and that those attacks came from an IP address associated with a rival in the space.

The tech startup, IQ.Lvbs, described the alleged security incident in a recent blog post.

On October 3, IQ.Lvbs introduced the private beta of NovaSpark, the first model for the company's IQ.Pilot app, in the Comma.ai Discord channel. They put it in that channel because the model requires the use of Comma.ai's camera hardware, which is built for self-driving vehicles.

From there, things got weird.

"From October 7 to 14, we faced repeated attempts to steal NovaSpark, access users' devices and private driving files, and exploit our sign-in system," the IQ.Lvbs blog post claims. "The first requests came from an IP assigned to Comma.ai Inc."

In addition, on October 8 – shortly after the alleged attacks began – somebody banned IQ.Lvbs' team from the Comma.ai Discord channel. Posts on the IQ.Pilot Discord channel indicate that individuals doing private beta testing for IQ.Lvbs have also been banned from that channel.

One of the three people involved in IQ.Lvbs, a UI/UX designer who asked to be identified only as "Cat," speculated to The Register about the reasons for the alleged hack and Discord ban.

"Our model, NovaSpark, is a good deal ahead of Comma's latest small and large models, which directly threatens their core business of making AI models good enough to sell their hardware," he said. "Comma for the most part has been stagnant in their models' improvement and that was a main driver for us making NovaSpark."

An October 7, 2026 Discord message from user Torq_boi, said to be Harald Schäfer, Comma.ai's CTO, implies NovaSpark was distilled from Comma.ai's Rebellious Hope model.

"I'm glad people are training models and experimenting with this stuff," the post starts. "But don't lie to people about what you're doing, and saying it's not a finetune of existing comma models when it is. That's not cool."

IQ.Lvbs disputes that assertion and says it did the work on its own. "The claim that NovaSpark is Rebellious Hope with a short fine-tune and an unchanged policy does not survive scrutiny, and we're not sure how Comma came to that conclusion, especially considering that they do not possess NovaSpark's model weights or ONNX," the biz said.

In the log data IQ.Lvbs published to support its claims, the company flags the username haraschax as one of those associated with Comma.ai IP addresses. Schäfer uses that username on GitHub.

Comma.ai and Schäfer did not respond to requests for comment sent to several different addresses. The Discord user Torq_boi in the Comma.ai channel did not respond to a DM seeking comment.

Comma.ai is currently being investigated [PDF] by the National Highway Traffic Safety Administration to assess whether its driving automation tech contributed to five crashes and three deaths.

IQ.Lvbs says it's considering legal action over the alleged hack. "We are currently reviewing our legal options and looking into involving the authorities," said Cat.


Original Submission

posted by jelizondo on Thursday October 29, @04:15AM   Printer-friendly
from the when-will-the-payoff-come dept.

Despite massive investments and widespread hype around artificial intelligence, the technology has delivered zero financial payoff to corporate America outside of tech.

In the analysis published on Saturday, Apollo Global Management Inc. said that the "S&P 493," which refers to the S&P 500 minus technology firms Alphabet Inc., Amazon.com Inc., Apple Inc., Meta Platforms Inc., Microsoft Corp., Nvidia Corp. and Tesla Inc., has not yet benefited from its investments in AI.

... while the Magnificent Seven has seen real profits from AI, the profit margins and revenue per worker of other companies remains flat, with no evidence that the technology is enhancing productivity. "Mainstream corporate America is pulling back and starting to view token spending not as a source of growth but as a cost center that weighs on margins,"

"Mainstream corporate America does not need the latest model and is unwilling to pay for it," he wrote. "As long as agentic AI and token spending are confined to a small part of the economy, the macroeconomic effects of AI will be very limited."

More analysis pointing in the direction of that the main beneficiaries from the AI-revolution are a handful of companies. The rest are desperately trying to find profit in their massive investments. When there is a gold rush sell shovels and pans still appears to be the valid business strategy? How long will the keep investing for that ever elusive future payoff day? To deep in the hole to stop digging?

https://siliconangle.com/2026/10/25/apollo-analysis-shows-that-no-one-apart-from-the-biggest-tech-giants-is-seeing-any-real-benefits-from-ai/
https://www.apollo.com/wealth/insights-news/insights/daily-spark/no-signs-of-ai-payoff-outside-the-tech-sector


Original Submission

[Ed's Note: Title corrected-20261029:10:57Z]

posted by hubie on Wednesday October 28, @11:32PM   Printer-friendly
from the live-and-let-drive dept.

Can we stop the progesssion of technology? Should we? Do disruptive cycles help or hinder us? Australia is about to find out as robotaxis roll their way down under to challenge the current fragile taxi ecosystem dominated by the much maligned taxi corporations and their down but not out Uber clone frenemies.

Who will win? The corporate humans with their outrageous flag falls with dodgy fare counters, the new comers with their mobile apps and surge pricing, or the driverless carriages that can't rip you off by demanding cash?


Original Submission

posted by hubie on Wednesday October 28, @06:46PM   Printer-friendly

Not to kill the human, of course – to kill the antibiotic-resistant bacteria causing their infection:

Researchers have administered AI-designed, bacteria-targeting viruses to a person in what they claim is a first, but don't press them for results: They're not ready to say how it went quite yet.

Radical Numerics, a San Francisco-based AI lab developing AI models for bioscience, announced the treatment this week, claiming it marks the first time a cocktail containing AI-designed bacteriophages has been administered to a human patient under a compassionate-use arrangement.

These aren't just any viruses, mind you: Omnii-1, the AI model publicly unveiled by Radical Numerics this week, was used to design viable bacteriophages, a type of virus that specifically infects bacteria.

Therapeutic use of phages isn't novel in and of itself, with the bacteria-targeting viruses being sought as an alternative to combat the rise of antimicrobial-resistant bacteria that are increasingly rendering antibiotics ineffective. 

Phages have a number of potential advantages over antibiotics, most notably their ability to target specific bacterial strains – a big plus when it comes to sparing beneficial gut bacteria that can be affected by broad-spectrum antibiotics.

AI has already shown promise in speeding up phage engineering, as we reported last year when a group of researchers from Stanford University and the Arc Institute created AI-designed phages that targeted E. coli bacteria. The phages, designed using the genetic sequence of a well-studied natural E. coli phage, included several variants that outperformed their biological predecessor in laboratory tests.

Similar to the Stanford work, which is referenced in Radical Numerics' write-up, the company used its own AI model to design bacteriophages, which it then tested against bacteria isolated from the antibiotic-resistant infection its patient was suffering from.

"The cocktail containing Omnii-1-designed phage variants eliminated the patient's antibiotic-resistant isolate in vitro," the company explained, so there's at least a success on record there. "The investigational cocktail was subsequently administered to the patient under compassionate use."

Unfortunately, that's where the trail of results ends, as Radical Numerics didn't publish anything about the results of testing the phage in a human, citing the need to protect their privacy. The company also doesn't want to give the impression that its AI phage therapy is generally safe or effective, noting that observations from a single patient don't establish much of anything. 

It's not even stated what infection the patient was suffering from, though the research write-up does mention testing Omnii-1's ability to predict which phages could infect Pseudomonas aeruginosa, a bacterium that can develop antibiotic resistance and cause infections in patients with burns and other wounds, as well as persistent lung infections in cystic fibrosis patients. The AI model "performed competitively" against a specialized model at predicting phage-host interactions, the research write-up notes.

There's nothing in the paper to suggest the patient was suffering from a Pseudomonas aeruginosa infection.

"This marks an important milestone in translating AI-designed biology from computational predictions and laboratory validation to clinical administration," Radical Numerics said of its work. The treatment takes the technology beyond laboratory testing, even if it turns out not to fully eliminate the infection. Radical Numerics hopes its work will lead to a process for designing and building phages targeted to individual bacterial infections, and the need for alternatives is already pressing – antibiotic resistance is a growing global health threat, with drug-resistant infections already causing substantial mortality worldwide.


Original Submission

posted by hubie on Wednesday October 28, @02:01PM   Printer-friendly

The Russian official who called commercial satellites "legitimate targets" now says concerns are "unfounded":

Four years ago, a senior official in Russia's foreign ministry painted a bullseye on commercial satellite networks that assist Ukraine in its fight against invading Russian military forces.

On Wednesday, several days after a Russian military spacecraft moved within striking distance of one of those commercial satellites, the same Russian diplomat assured the world there's no reason to worry.

There's a sharp incongruity in those statements from Konstantin Vorontsov, deputy head of Russia's delegation to the United Nations. Vorontsov's comments Wednesday in the UN General Assembly's First Committee came moments after a US official called attention to recent maneuvers by Kosmos 2612, a Russian military craft that approached a US-registered commercial satellite some 340 miles (550 kilometers) above Earth.

"Just last weekend, Russia's Ministry of Defense Kosmos 2612 exhibited threatening behavior by intentionally maneuvering dangerously close to a commercial satellite," Brian Hardesty, a US State Department official, told the UN committee. "These behaviors appear consistent with an on-orbit weapons operation. The decision to conduct these activities was deliberately reckless and violated long-established safety thresholds in low-Earth orbit."

[...] Vorontsov said the US government's concerns, echoed by European officials, were "unfounded" distractions. "Western countries headed by the United States continue to use loudspeaker diplomacy repeating absurd accusations about Russia's space activity."

All Russian activity in space is "purely peaceful in character," Vorontsov said. "This applies to the activity related to Kosmos 2612."

Vorontsov's statements in 2022 were more provocative. At that time, as Ukraine ramped up its reliance on commercial satellite communications and surveillance, Vorontsov said that commercial space infrastructure used by Ukraine's military, including Western satellites, could be a "legitimate target for a retaliatory strike."

It is no wonder, then, that the Russian military's unprecedented maneuvers near one of those satellites raised alarms. Since its launch in April, Kosmos 2612 performed a series of carefully choreographed rocket burns to match orbits with ICEYE-X36, a radar surveillance satellite owned by the US subsidiary of the Finnish remote sensing company ICEYE.

[...] Last week, Kosmos 2612 moved closer and held position in "extreme proximity" to ICEYE-X36, according to orbital intelligence company LeoLabs. An executive at LeoLabs told Ars on Monday that Kosmos 2612 moved within 500 meters (about 1,640 feet) of the ICEYE satellite, and likely much closer. An image from Vantor, a satellite remote-sensing company, first published by Axios, showed the satellites about 1 kilometer apart on Saturday.

Taylor suggested Wednesday that Kosmos 2612 may have ultimately closed within a range of 100 feet. It's hard to know for sure due to the limitations of satellite tracking.

"I would note that Russia did not attempt to explain why a Russian military satellite moved within tens of meters of another country's commercial satellite," Taylor said. "The decision to conduct operations violated long-established safety thresholds in low-Earth orbit."

Kosmos 2612 backed off from ICEYE-X36 without firing a shot and is orbiting far away, although its trajectory does not preclude attempting another approach.

[...] Much of the discussion at the UN on Wednesday focused on proposals by Russia and China for an international agreement to ban the placement of any weapons in space. US officials say such proposals are moot because the world's leading space powers already possess them. There's also the thorny question of how to determine what constitutes a weapon in space, where ramming and jamming could be done by conventional technologies flying on many kinds of satellites.

Such blanket bans are "ineffectual and unrealistic," Hardesty said. They would "inevitably be violated by its proponents while interfering with our ability to defend against those who would cheat on their obligations."

Instead, US officials have underscored a tenet of the 1967 Outer Space Treaty, which bans weapons of mass destruction in orbit. In 2024, under the Biden administration, the United States proposed a resolution in the UN Security Council that would have reaffirmed the ban, two months after a US intelligence leak suggested Russia was developing a nuclear-armed anti-satellite weapon. Russia vetoed the UN resolution.


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posted by jelizondo on Wednesday October 28, @09:18AM   Printer-friendly

Walter Koenig, actor best known as Chekov on Star Trek, dies aged 90:

Walter Koenig, the actor known for playing Pavel Chekov throughout the Star Trek franchise, has died, his representative confirmed to the Hollywood Reporter . He was 90.

Koenig died at his home in North Hollywood surrounded by his daughter and niece, according to a Facebook post by Zachery McGinnis, the founder of Galactic Productions, an appearance agency that counted the actor as one of its clients. His death was attributed to "old age", with no other details provided.

"Today we mourn the passing of Walter Koenig, whose talent, warmth, and unforgettable performances left a lasting mark on generations of fans around the world," McGinnis wrote. "Walter's legacy extends far beyond the screen. Through countless convention appearances and interactions with fans, he shared his kindness, wit, and appreciation with everyone fortunate enough to meet him. He understood what Star Trek meant to people and embraced the community that grew around it."

The post concluded: "Thank you, Walter, for the memories, the inspiration, and for boldly going where few have gone before."

"My heart is heavy," wrote Koenig's Star Trek co-star George Takei on Facebook on Monday. Takei first met Koenig in the 1960s, "on the bridge of the Enterprise" and remained friends for six decades; Koenig served as Takei's best man at his wedding in 2008.

"Walter was more than Chekov. He was a writer, a teacher, a thoughtful man, and a loyal friend," Takei wrote. "To the fans who loved him for so many years, thank you. He loved you too. Rest well, my dear friend. Keep navigating a steady course."

Jesse Thorn, the host of the NPR show Bullseye, also confirmed the news on Bluesky , citing his friend Danielle Koenig, the late actor's daughter. "Something I was struck by knowing Danielle, her husband and her late brother Andrew (and talking with George Takei) was the very sincere love those Star Trek cast members had for each other," he wrote. "That whole thing was thrust upon them and their obvious deep friendship was so clear. What a gift."

Born in Chicago but raised in Manhattan as the child of Lithuanian immigrants, Koenig began his acting career in 1962, with an uncredited role as a sentry in Combat!. He joined Star Trek for the start of the second season and appeared in 36 of the 50 episodes that aired between 1967 and 1969.

He continued his role as the Russian Chekov in the first seven Paramount movies derived from the show, released between 1979 and 1991, as well as in a two-part crowdsourced Renegades series that debuted online in 2017. He most recently reprised the voice of Chekov in a 2023 episode of the animated series Star Trek: Picard.

Koenig also worked as a writer, penning episodes for such series as The Powers of Matthew Star, Family, Land of the Lost and The Incredible Hulk. He wrote, produced and starred in the 2010 sci-film InAlienable, starring Richard Hatch.

Koenig was married to the actor Judy Levitt, with whom he appeared in three Star Trek movies as well as another acclaimed sci-fi series, Babylon 5, which ran from 1994 until 1998. The couple were together from 1965 until her death in December 2022 at the age of 83. Their son Andrew, who played Richard "Boner" Stabone in the ABC sitcom Growing Pains, died in 2010 at age 41.

Koenig is survived by his daughter, the actor and screenwriter Danielle Koenig.


Original Submission

posted by jelizondo on Wednesday October 28, @04:36AM   Printer-friendly

Researchers at the Max Planck Institute of Geoanthropology criticise how the decision to reject the Anthropocene as a geological epoch was reached and call for an independent review:

In a recent article in Earth's Future, researchers at the Max Planck Institute of Geoanthropology criticise the process by which the Anthropocene was rejected as a new geological epoch in 2024. They call on the International Union of Geological Sciences (IUGS) to disclose relevant documents and submit the decision-making process to an independent review.

The term Anthropocene was coined in 2000 and describes humans as a major driver of changes in the Earth system. Since then, the concept has gained importance in science, society, culture and law. The Anthropocene Working Group (AWG) proposed formally recognising the Anthropocene as a geological epoch. This proposal was rejected by the IUGS in 2024.

Now, a new commentary paper by authors from the Max Planck Institute of Geoanthropology calls on the IUGS to fully disclose the relevant documentation, as well as for an independent procedural review of the decision.

The paper documents procedural violations that cast doubt on the legitimacy of the IUGS' decision, the authors argue.

"Our main concern isn't the rejection itself. A proposal can legitimately be rejected," says Georg Schäfer, lead author of the paper. "The issue is that no adequate scientific justification for it was ever published, and serious allegations on procedural inconsistencies remain unaddressed."

Those procedural concerns include a compromised evaluation, in which the Anthropocene Working Group could not address comments or make revisions, and an invalid voting process, in which the majority of votes cast were invalid under the body's rules. An internal ethics report investigating these violations, which the IUGS executive committee did not act upon, remains publicly inaccessible.

"The Anthropocene epoch proposal demands transparency and procedural legitimacy," says Professor Jürgen Renn, founding director of the Max Planck Institute of Geoanthropology. "If decisions regarding a humanity-induced planetary crisis can be made behind closed doors, with key documents withheld and public communication vague or contradictory, then geoscience's capacity to inform societal understanding of Earth system change is diminished."

Previously:
    • Geologists Reject Declaration of 'Human Era' in Earth's Timeline
    • For the Second Time, We Are Witnessing a New Geological Epoch: The Anthropocene

Journal Reference: Science or Strategy? The Rejection of the Anthropocene Epoch Demands Transparency: https://doi.org/10.1029/2025EF007638


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